지속가능한 건강한 사회를 만들기 위해서 그린바이오/산업바이오 분야 산업미생물 개발하고 연구 가속화를 위해서 자동화 플랫폼/유전자편집 플랫폼 연구를 수행합니다.
(주제) 그린바이오 소재개발, 산업바이오 융합기술, 생물공학, 생물전환기술
(기술) 합성생물학, 대사공학, CRISPR-Cas, BioFoundry
(소재) 산업미생물, 박테리아
Microbial cell designs to produce valuable chemicals such as biofuels, biomaterials, and biochemicals etc. from renewable resources i.e. biomass and carbon dioxide using recent genetic engineering tools (CRISPR genetics, Metabolic engineering and Synthetic Biology).
학력
2023, University of California, Berkeley, Visiting Scholar
2011, Lawrence Berkeley National Laboratory 박사후연구원
2010, Heinrich Heine Universität Düsseldorf 미생물학 박사 (율리히연구소)
2006, KAIST 생명화학공학과 석사
2004, 고려대학교 화공생명공학과 학사
약력/경력
06.2015 – Present: Editorial Board Member in Microbiology, Scientific Reports, Nature Publishing Group
09.2012 – 08.2016: Adjunct Professor, Green School (Graduate School of Energy and Environment), Korea University, Seoul, South Korea 11.2011 – 08.2016: Senior Research Scientist, Clean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea
11.2010 – 10.2011: Biologist Postdoctoral Fellow, Lawrence Berkeley National Laboratory, Joint BioEnergy Institute, Emeryville, CA, USA 94608
학술지 논문
(2024)
CRISPR-dCas13a system for programmable small RNAs and polycistronic mRNA repressions in bacteria.
NUCLEIC ACIDS RESEARCH.
52,
1
(2023)
Photosynthetic Cyanobacteria can Clearly Induce Efficient Muscle Tissue Regeneration of Bioprinted Cell-Constructs.
ADVANCED FUNCTIONAL MATERIALS.
33,
10
(2023)
Cytosine base editing in cyanobacteria by repressing archaic Type IV uracil-DNA glycosylase.
PLANT JOURNAL.
113,
3
(2022)
High-Fidelity Cytosine Base Editing in a GC-Rich Corynebacterium glutamicum with Reduced DNA Off-Target Editing Effects.
MICROBIOLOGY SPECTRUM.
10,
6
(2022)
Co-production of L-Lysine and Heterologous Squalene in CRISPR/dCas9-Assisted Corynebacterium glutamicum (vol 70, pg 14755, 2022).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
70,
48
(2022)
Biofoundry Palette: Planning-Assistant Software for Liquid Handler- Based Experimentation and Operation in the Biofoundry Workflow.
ACS SYNTHETIC BIOLOGY.
11,
10
(2022)
DeepTESR: A Deep Learning Framework to Predict the Degree of Translational Elongation Short Ramp for Gene Expression Control.
ACS SYNTHETIC BIOLOGY.
11,
5
(2022)
RoboMoClo: A Robotics-Assisted Modular Cloning Framework for Multiple Gene Assembly in Biofoundry.
ACS SYNTHETIC BIOLOGY.
11,
3
(2021)
Microbial Bioprocess for Extracellular Squalene Production and Formulation of Nanoemulsions.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING.
9,
42
(2021)
Hybrid Embden-Meyerhof-Parnas Pathway for Reducing CO2 Loss and Increasing the Acetyl-CoA Levels during Microbial Fermentation.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING.
9,
36
(2021)
Improved CO2-derived polyhydroxybutyrate (PHB) production by engineering fast-growing cyanobacterium Synechococcus elongatus UTEX 2973 for potential utilization of flue gas.
BIORESOURCE TECHNOLOGY.
327,
-
(2021)
Biocontainment of Engineered Synechococcus elongatus PCC 7942 for Photosynthetic Production of alpha-Farnesene from CO2.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
69,
2
(2021)
Evaluation of photosynthetic squalene production of engineered cyanobacteria using the chemical inducer-free expression system.
Microbiology and Biotechnology Letters.
49,
3
(2020)
Metabolic Engineering and Synthetic Biology of Cyanobacteria for Carbon Capture and Utilization.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING.
25,
6
(2020)
A Logic NAND Gate for Controlling Gene Expression in a Circadian Rhythm in Cyanobacteria.
ACS SYNTHETIC BIOLOGY.
9,
12
(2020)
Biosynthesis of the Calorie-Free Sweetener Precursor ent-Kaurenoic Acid from CO2 Using Engineered Cyanobacteria.
ACS SYNTHETIC BIOLOGY.
9,
11
(2020)
Current understanding of the cyanobacterial CRISPR-Cas systems and development of the synthetic CRISPR-Cas systems for cyanobacteria.
ENZYME AND MICROBIAL TECHNOLOGY.
140,
-
(2020)
Overexpression of the Key Enzymes in the Methylerythritol 4-phosphate Pathway in Corynebacterium glutamicum for Improving Farnesyl Diphosphate-Derived Terpene Production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
68,
39
(2020)
CRISPRi-dCas12a: A dCas12a-Mediated CRISPR Interference for Repression of Multiple Genes and Metabolic Engineering in Cyanobacteria.
ACS SYNTHETIC BIOLOGY.
9,
9
(2020)
Scalable Cultivation of Engineered Cyanobacteria for Squalene Production from Industrial Flue Gas in a Closed Photobioreactor.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
68,
37
단행본
(2018)
Emerging Areas in Bioengineering
Chang, Ho Nam (ed.) Advanced Biotechnology (Series Nr. 7)
Han Min Woo. 29. Synthetic Biology for Corynebacterium glutamicum, and Industrial Host for White Biotechnology.
Wiley-VCH.
단독
특허/프로그램
하이브리드형 해당경로.
10-2020-0014711.
20210511.
대한민국
목적 유전자의 발현을 조기 종결하기 위한 벡터 및 이를 포함하는 균주.
10-2019-0004662.
20201021.
대한민국
이산화탄소로부터의 파넨신 생성능을 갖는 형질전환된 시네코코커스 일롱케투스 균주.
16/149,750.
20200512.
미국
스쿠알렌 생성능을 가지는 형질전환된 코리네박테리움 글루타미쿰.
10-2018-0005193.
20200220.
대한민국
타겟유전자 발현 조절을 위한 대장균/코리네박테리움 글루타미쿰의 셔틀벡터.
10-2017-0099545.
20190923.
대한민국
재조합 코리네박테리움 글루타미쿰을 이용한 부티레이트 생산.
10-2018-0011955.
20190611.
대한민국
파넨신 생성능을 갖는 형질전환된 시네코코커스 일롱케투스 균주 및 이의 용도.
10-2017-0137227.
20190429.
대한민국
이산화탄소로부터의 아세톤 생산능을 갖는 형질전환된 시네코코커스 일롱게투스 균주 및 이를 이용한 아세톤 생산방법.
10-2017-0172856.
20190305.
대한민국
Expression vector for cyanobacteria.
860373 .
20170801.
미국
Transformed Synechococcus elongatus having capability of producing acetone from carbon dioxide.
057551 .
20170627.
미국
이산화탄소로부터 아세톤 생성능을 갖는 형질전환된 시네코코코스 일롱케투스 균주.
10-2015-0030616.
20170619.
대한민국
수상/공훈
Miewon Best Young Scientist, The Korean Society of Industrial and Engineering Chemistry, Dae-gu, May 2 (2018)
Unsung Hero Award (Best Research Performance award), Korea Institute of Science and Technology, Seoul, December 17 (2014)
Young Investigator Poster Award, Synthetic Biology and Metabolic Engineering Award, Metabolic Engineering IX, Biarritz, France, June 6 (2012)
Travel Award, The fifth International Conference of the Metabolomics Society, Edmonton, Canada, September (2009)
Best Poster Award, Korean Society of Toxicology, Seoul, November (2006)
CJ Bio Award, CJ Group- KiChE, Seoul, December (2004)
3M Honorable award, the certificate of achievement - Innovation at 3M, 3M Korea, Seoul, November (2003)
Korean Institute of Chemical Engineers Scholarships, Korea University-KiChE, Seoul, March & September (2003)
Best Honors Scholarships, Korea University, Seoul, September (2002)
학술회의논문
(2018)
Metabolic engineering of cyanobacteria for bio-diesel candidates (fatty acid ethyl ester and farnesene) from CO2.
The 1st Asia and Oceania Congress on Photosynthesis.
중국
(2018)
Direct Conversion of Carbon Dioxide to Value-Added Chemicals Using Engineered Cyanobacteria.
International Conference on Biomolecular Engineering.
싱가포르
(2018)
Improvement of direct conversion of CO2 to squalene in engineered cyanobacteria.
International Conference on Biomolecular Engineering.
싱가포르
(2018)
Synthetic Biological Platform of CoryneBrick vectors and its Application to Improve Xylose Utilization and Cell growth in Corynebacterium glutamicum.
International Conference on Biomolecular Engineering.
싱가포르
(2017)
IMPROVEMENT OF DIRECT CONVERSION OF CO2 TO SQUALENE BY METABOLICALLY ENGINEERED IN CYANOBACTERIA.
8th Asia and Oceania Conference on Photobiology.
대한민국
(2017)
Direct conversion of CO2 to value-added chemicals using engineered cyanobacteria”, 13th international Symposium on Biocatalysis and Biotranformations.
13th International Symposium on Biocatalysis and Biotransformations.
헝가리
